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KMID : 0378019840270030077
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New Medical Journal
1984 Volume.27 No. 3 p.77 ~ p.87
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Clinical and Experimental Studies on the Effect of Panax Ginseng upon Alcoholic Liver Injury
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Abstract
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With an increased consumption of alcoholic beverages, the occurrence of corresponding liver disease has bean steadily increased. However, it seams that the relevant treatments on this disease are still symptomatic and conservative. While panax ginseng has been traditionally used as a marvelous tonic in the orient, its effects accelerating repair of injury and detoxication have been reported.
These studies were conducted clinically and experimentally to evaluate the effect of panax ginseng upon alcoholic liver disease.
Clinically, 40 patients with alcoholic hepatitis were selected and divided into 1) control group given regular remedy and 2) ginseng group administered panax ginseng powder and regular remedy
Panax ginseng powder was administered orally 5gm per day.
A. The results obtained from this clinical study indicated that serum enzyme (GOT, GPT, alkaline phosphatse) and bilirubin level in ginseng treated group were decreased in comparison with those of control group.
Experimentally, 72 healthy Sprague-Dawley rat weighing around 200gm were used for this experiment and divided into 1) control group fed basic diet 2) alcohol groups administered 25%, 40% alcoholic beverage, 3) alcohol-ginseng groups treated 25%, 40% alcoholic beverages and panax ginseng powder and 4) ginseng group given only panax ginseng powder.
Alcoholic beverages was given orally l0ml per day
Panax ginseng powder was administered orally 50mg per day
B. The results obtained from this experimental study were as follows:
l. Control and ginseng treated groups revealed no significant changes, serologically and histologically.
2. In alcohol administered groups, serum enzyme and bilirubin levels were elevated, and histologically, swelling of hepatic cord cells, congestion, bile pigmentation and fatty degeneration were noted.
3. In alcohol and ginseng treated groups, serum enzyme and bilirubin levels were decreased compared with those of alcohol administered groups, and histologic changes such as swelling of hepatic cord cells, bile pigmentation and fatty degeneration were obviously subsided in comparison with that of alcohol administered group.
All above data obtained from the clinical and experimental studies indicated that panax ginseng reduced histopathological changes as well as lowered elevated serum enzyme and bilirubin levels.
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